Beilstein J. Nanotechnol.2020,11, 1381–1393, doi:10.3762/bjnano.11.122
, that is, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) and NaH2PO4, decreased the ability of γ-Fe2O3 nanoparticles to form a glutamatebiocoating by about 50% and 90%, respectively. Only 15% of the amount of glutamatebiocoating obtained in water was obtained in blood plasma. Albumin did
not prevent the formation of a glutamatebiocoating. It was shown that the glutamatebiocoating is a temporal dynamic structure at the surface of γ-Fe2O3 nanoparticles. Also, components of the nerve terminal incubation medium and physiological fluids responsible for the desorption of glutamate were
transient glutamatebiocoating can be useful for multifunctional theranostics.
Keywords: blood plasma; brain nerve terminals; glutamatebiocoating; maghemite (γ-Fe2O3) nanoparticles; protein biocorona; Introduction
Glutamate is a main fast excitatory neurotransmitter in the central nervous system. Normal
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Figure 1:
TEM micrograph of γ-Fe2O3 nanoparticles.